Liver The flavonoid and terpenoid components of these herbal

Liver disease is the only major cause of death still increasing
year-on-year. Liver disease is one of the most common causes of
mortality in India. Currently, India is ranked at 27 in the list of countries
affected by various liver disorders. Alcohol is one of the major causes of
morbidity and mortality in high, middle, and low-income countries. In India,
liver failure is highly attributed to alcoholism. Liver
disease is the fifth ‘big killer’, after heart, cancer, stroke and respiratory
disease. The statistics are not comprehensive, but liver death to other codes
as liver disease frequently causes multiple organ dysfunctions.

In
India, more than 300 market preparations (some of them Adliv Forte capsule,
Livosr tablet, Nirocil tablet & syrup, Tonoli tablet, Vimliv syrup, Muliv
strong syrup, Livotrit tablet, Herbitarss tablet etc.)  made from 87 herbal plants are available for
treatment of Jaundice and other chronic liver disorders.These herbal drugs
include Silymarin, Phyllanthin, Lecithin, Catechin, Glycyrrhizin, Picroside,
Baicalein, Daphnoretin etc. In majority of traditional systems, liver diseases
is better managed by the herbs combination (Polyherbal) instead of single herb
because of synergism and less side effects.

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The
problem associated with the use of herbal preparation is of their poor
bioavailability. Phytoconstituents like flavonoids, polyphenols, tannins,
terpenoids etc., are poorly absorbed due to their large molecular size (which
cannot be absorbed by passive diffusion). Also due to their poor lipid
solubility, it severely limits its ability to pass across the lipid-rich biological
membranes. The vesicle system composed of phospholipids can increase the
therapeutic value, reduce toxicity and can increase the bioavailability of the
phytomedicines. The phospholipid-based vesicle system, mainly phytosomes, has
been applied recently to many popular herbal extracts including Ginkgo biloba, grape seed,
hawthorn, milk thistle, green tea and ginseng. The flavonoid and terpenoid
components of these herbal extracts lend themselves quite well for the direct
binding to phosphatidylcholine. The binding of components of herbal extracts to
phosphatidylcholine results in a dosage form that is better absorbed and thus
produces better results than the conventional dosage form. The reports indicate
that the absorption of Silybin from Silybin phytosome is approximately seven
times higher compared to the absorption of Silybin from regular milk thistle
extract. Bombardelliet al.
(1991) reported that the silymarin phospholipid complex showed much higher
antioxidant, free radical scavenging properties and a long lasting action than
the silymarin alone. Hence, in the proposed study plan to develop polyherbal
hepatoprotective formulation incorporated in the phospholipids vesicle system.

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