The the results of amimal experiment. Though BHA is

The
National Toxicology Program in 2005 mentioned BHA as “reasonably anticipated to
be a human carcinogen” by the results of amimal experiment. Though BHA is
continued to approved by the Food and Drug to sell in market, several research articles
showed that this antioxidant has negative effects. In the book “The
Undeniable Truth about Food”, Kylie Floate comments that a part of BHA is
not excreted by body. There is a reasonable amount of research to suggest that
BHA is a human carcinogen, as well, Not only Department of Health and Human
Services National Toxicology Program, but also some trusted researches
recommend BHA is responsible for carcinogenesis.

BHA
is marked as a Category 1 endocrine disruptor by The European Commission on
Endocrine Disruption. It is reasonable evidence of endocrine disrupting
effects. California’s Proposition 65 also denotes this antioxidant as a human
carcinogen. On the other hand, some people say that BHA will not influence the
health if body just absorb small amount. But it is not easy to control the dose
of this chemical since it is found in so many products not only food but also
personal care. In addition, endocrine disrupting substances mostly activate  at very low concentration.

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According
to carcinogenicity tests, F344 rats comsumes the diet with the addtion of BHA that
has high risk to develope papilloma and squamous cell carcinoma of the
forestomach of both sexes. Male hamsters, which were digested BHA for 24 weeks,
also increased the incidences of papilloma showing reduced growth into the
submucosa of the forestomach. These results indicate that International Agency
for Research on Cancer (IARC) should classify BHA in the category of
“sufficient evidence of carcinogenicity”. The 3-tert isomer of BHA
seemed to be responsible for the carcinogenicity of crude BHA in the
forestomach of rats. In two-stage carcinogenesis in rats after appropriate
initiation, BHA enhanced carcinogenesis in the forestomach and urinary bladder
of rats, but inhibited carcinogenesis in the liver. 

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